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Kazutetsu Aoshiba Selected Research

Pulmonary Emphysema

1/2017Improvement of metabolic disorders by an EP2 receptor agonist via restoration of the subcutaneous adipose tissue in pulmonary emphysema.
8/2014Promotion of adipogenesis by an EP2 receptor agonist via stimulation of angiogenesis in pulmonary emphysema.
6/2012Superiority of PC-SOD to other anti-COPD drugs for elastase-induced emphysema and alteration in lung mechanics and respiratory function in mice.
10/2011[Roles of apoptosis, cell senescence, and DNA damage in the pathogenetic mechanism of COPD].
9/2011Therapeutic effect of lecithinized superoxide dismutase on pulmonary emphysema.
4/2007[Role of alveolar cell apoptosis in COPD].
3/2004Differences in the distribution of CD4+ and CD8+ T cells in emphysematous lungs.

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Kazutetsu Aoshiba Research Topics

Disease

17Inflammation (Inflammations)
03/2016 - 01/2003
12Chronic Obstructive Pulmonary Disease (COPD)
10/2021 - 08/2004
7Lung Neoplasms (Lung Cancer)
12/2020 - 02/2004
7Pulmonary Emphysema
01/2017 - 03/2004
6Fibrosis (Cirrhosis)
01/2018 - 08/2003
6Emphysema
05/2015 - 02/2004
5Neoplasms (Cancer)
10/2021 - 12/2004
5Asthma (Bronchial Asthma)
10/2021 - 01/2003
3Pulmonary Fibrosis (Fibrosing Alveolitis)
07/2021 - 08/2003
3Acidosis
12/2020 - 11/2017
3Pneumonia (Pneumonitis)
01/2018 - 08/2009
3Lung Diseases (Lung Disease)
01/2016 - 08/2003
3Wounds and Injuries (Trauma)
06/2011 - 06/2002
2Dyspnea (Shortness of Breath)
01/2019 - 01/2015
2Hemorrhage
03/2018 - 01/2015
2Hypertrophy
11/2017 - 08/2004
2Hyperplasia
10/2016 - 08/2004
2Neoplasm Metastasis (Metastasis)
01/2016 - 03/2013
2Airway Remodeling
05/2015 - 05/2014
1Polymyositis
12/2021
1Malignant Mesothelioma
10/2021
1COVID-19
10/2021
1Extrinsic Allergic Alveolitis (Hypersensitivity Pneumonitis)
10/2021
1Paraneoplastic Syndromes (Paraneoplastic Syndrome)
10/2021
1Hypoglycemia (Reactive Hypoglycemia)
10/2021
1Infections
01/2021
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
02/2020
1Encephalitis (Encephalitis, Rasmussen)
01/2019
1Fever (Fevers)
01/2019
1Pulmonary Eosinophilia (Eosinophilic Pneumonia)
01/2019
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
01/2019
1Pulmonary Edema
03/2018
1Hypercapnia
11/2017
1Hypocapnia
11/2017
1Secondary Hypertrophic Osteoarthropathy
01/2017
1Bronchiolitis Obliterans Syndrome
10/2016
1Tuberculosis (Tuberculoses)
07/2016

Drug/Important Bio-Agent (IBA)

6Pancreatic Elastase (Elastase)IBA
01/2017 - 01/2006
5Therapeutic UsesIBA
10/2021 - 03/2009
5CytokinesIBA
10/2011 - 01/2003
4SmokeIBA
10/2021 - 07/2006
4Peptide Hydrolases (Proteases)FDA Link
10/2011 - 05/2006
3SteroidsIBA
12/2021 - 06/2012
3Proteins (Proteins, Gene)FDA Link
12/2020 - 12/2004
3C-Reactive ProteinIBA
02/2020 - 05/2006
3Oxidants (Oxidizing Agents)IBA
01/2019 - 06/2002
3NF-kappa B (NF-kB)IBA
01/2010 - 01/2006
2GlucocorticoidsIBA
10/2021 - 10/2021
2Pharmaceutical PreparationsIBA
10/2021 - 06/2012
2RoflumilastIBA
10/2021 - 06/2012
2Peroxisome Proliferator-Activated Receptors (PPAR)IBA
07/2021 - 11/2017
2LipidsIBA
07/2021 - 01/2018
2Glucose (Dextrose)FDA LinkGeneric
12/2020 - 01/2017
2ErbB Receptors (EGF Receptor)IBA
02/2020 - 08/2003
2naphthaleneIBA
10/2016 - 07/2014
2MacrolidesIBA
03/2016 - 05/2014
2Bromodeoxyuridine (BrdU)IBA
05/2015 - 06/2011
29- deoxy- 9- chloro- 15- deoxy- 16- hydroxy- 17,17- trimethylene- 19,20- didehydroprostaglandin E2IBA
08/2014 - 12/2009
2Transforming Growth Factor beta (TGF-beta)IBA
05/2014 - 04/2003
2DNA (Deoxyribonucleic Acid)IBA
12/2013 - 06/2012
2Reactive Oxygen Species (Oxygen Radicals)IBA
12/2013 - 08/2009
2Bleomycin (Blenoxane)FDA LinkGeneric
11/2013 - 08/2003
2Bronchodilator Agents (Bronchodilators)IBA
04/2013 - 06/2012
2lecithinized superoxide dismutaseIBA
06/2012 - 09/2011
2Superoxides (Superoxide)IBA
06/2012 - 09/2011
2Protease Inhibitors (Protease Inhibitor)IBA
09/2011 - 04/2007
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
03/2009 - 01/2006
1Dexamethasone (Maxidex)FDA LinkGeneric
10/2021
1OvalbuminIBA
10/2021
1PPAR alphaIBA
07/2021
1Fenofibrate (CiL)FDA LinkGeneric
07/2021
13- (5- tert- butylisoxazol- 3- yl)- 2- ((3- chlorophenyl)hydrazono)- 3- oxopropionitrileIBA
12/2020
1Adenosine Triphosphate (ATP)IBA
12/2020
1Carboplatin (JM8)FDA LinkGeneric
01/2019
1NivolumabIBA
01/2019
1Antineoplastic Agents (Antineoplastics)IBA
01/2019
1Cisplatin (Platino)FDA LinkGeneric
01/2019
1Etoposide (VP 16)FDA LinkGeneric
01/2019
1Pneumococcal Vaccines (Pneumococcal Polysaccharide Vaccine)IBA
01/2019
1Sitagliptin Phosphate (Januvia)FDA Link
03/2018
1Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
11/2017
1Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)IBA
11/2017
1Transcription Factors (Transcription Factor)IBA
11/2017
1CCAAT-Enhancer-Binding ProteinsIBA
11/2017
1Adenylyl Cyclases (Adenylyl Cyclase)IBA
11/2017
1Adenosine Monophosphate (AMP)IBA
11/2017
1Oxygen (Dioxygen)IBA
11/2017
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2017
1Rifampin (Rifampicin)FDA LinkGeneric
07/2016
1Ethambutol (Myambutol)FDA LinkGeneric
07/2016
1Isoniazid (Ftivazide)FDA LinkGeneric
07/2016
1FluoroquinolonesIBA
07/2016

Therapy/Procedure

5Drug Therapy (Chemotherapy)
10/2021 - 03/2013
5Therapeutics
10/2021 - 04/2013
2Pneumonectomy (Lung Volume Reduction)
03/2004 - 02/2004
1Glycemic Control
10/2021
1Humidifiers
10/2021
1Lasers (Laser)
01/2021
1Renal Dialysis (Hemodialysis)
01/2019
1Lung Transplantation
10/2016